Which type of drug is most likely to produce wakefulness and reduce drowsiness at a moderate dose?

• A. Barbiturates
• B. Sedatives
• C. Amphetamines
• D. Cannabis

Answer: (C)

Wakefulness at a moderate dose comes from stimulant drugs. Amphetamines are classic CNS stimulants that increase dopamine and norepinephrine in the brain, boosting alertness, concentration, and energy while reducing fatigue. At a moderate dose, these arousal effects are strong enough to counter drowsiness and promote wakefulness without producing the heavier sedation seen with depressants. Barbiturates and other sedatives depress CNS activity, so they promote sleepiness rather than wakefulness, and cannabis tends to have sedating effects for many people at typical doses. So, the drug type most likely to produce wakefulness and reduce drowsiness at a moderate dose is amphetamines.